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Q
which amino acid has three pka’s
I'm a seasoned industrial engineer with a keen interest in machine learning. Here to share insights on latest industry trends.
The amino acid that possesses three pKa values is aspartic acid (Asp or D). Amino acids are organic compounds that contain amine (-NH2) and carboxyl (-COOH) functional groups, along with a central carbon atom that holds a unique side chain (R group). Aspartic acid's R group contains two ionizable groups: one carboxyl group and one amino group. The typical pKa values of aspartic acid are approximately 1.9 (for the first carboxyl group), 3.7 (for the second carboxyl group), and 9.6 (for the amino group). These pKa values reflect the strength of the acid and determine the molecule's ionization state at various pH levels. The presence of three ionizable groups allows aspartic acid to act as an effective buffer over a wide pH range, making it essential in many biological processes, particularly in the stabilization of protein structure and function.
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