Q
how many amino acids in mut y glycosylase
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MutY glycosylase, an enzyme involved in DNA repair, does not have a universal size across all organisms, meaning the number of amino acids it consists of can vary. For instance, in Escherichia coli (E. coli), MutY is composed of approximately 350 amino acids. The function of MutY glycosylase is crucial for maintaining DNA integrity by excising adenines misincorporated opposite to 8-oxoguanine, a byproduct of oxidative damage. Without such mechanisms, the accumulation of mutations could lead to genomic instability and disease. The specific size and sequence of MutY glycosylase can depend on the species, reflecting the diversity in genetic makeup and adaptation to different environments or cellular processes. Research into the structural differences and functionalities across species can provide insights into DNA repair mechanisms and potential therapeutic targets for genetic diseases.
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