Q
what amino acids are involved in the urea cycle
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The urea cycle is a vital metabolic pathway occurring in the liver, facilitating the detoxification of ammonia by converting it into urea for excretion. Several amino acids play crucial roles in this cycle. Arginine is central to the cycle, as it gets converted to ornithine, which then reacts with carbamoyl phosphate to initiate the cycle. Citrulline, formed from ornithine and carbamoyl phosphate, combines with aspartate (another key amino acid) to form argininosuccinate, which later splits into arginine and fumarate, continuing the cycle. Aspartate and argininosuccinate are key intermediates, underscoring the importance of these amino acids in the smooth operation of the urea cycle, ensuring the safe disposal of ammonia and the maintenance of nitrogen balance in the body.
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