Q
what is kinetochore fibers
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Kinetochore fibers are key components of the mitotic spindle in cell division, particularly during mitosis and meiosis. They consist of microtubules that extend from centrosomes (spindle poles) and attach to chromosomes at structures known as kinetochores. Each chromosome has two kinetochores facing opposite spindle poles, ensuring chromosomes are accurately separated into the daughter cells. This attachment is crucial for the alignment of chromosomes at the metaphase plate and their subsequent segregation during anaphase. The dynamic assembly and disassembly of kinetochore fibers ensure precise chromosome movement and are vital for genetic stability and the prevention of aneuploidy, which can lead to diseases such as cancer.
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